The European Clinical Research Infrastructure Network (ECRIN, www.ecrin.org) is a sustainable, non-profit, distributed infrastructure with the legal status of a European Research Infrastructure Consortium (ERIC). ECRIN supports multinational clinical trials in Europe, which provide increased access to patients, resources and expertise. In particular, ECRIN supports investigators and sponsors in the planning and design of clinical trials, and can subsequently provide services for the management of multinational trials. ECRIN is also involved in activities to enhance the ability of European sponsors to successfully conduct multi-country clinical research (e.g. tools/database development, data centre certification). Moreover, ECRIN is involved in infrastructure development projects that aim to further develop the European clinical research community and facilitate multinational trials. ECRIN is a “distributed infrastructure” that includes a core team based in Paris, a network of European correspondents (EuCos), and national scientific partners in each member and observer country. As of 2019, ECRIN has nine member countries (Czech Republic, France, Germany, Hungary, Ireland, Italy, Norway, Portugal and Spain) and two observer countries (Switzerland and Slovakia).